Neuroprotective effect of Apelin 13 on ischemic stroke by activating AMPK/GSK-3β/Nrf2 signaling
Neuroprotective effect of Apelin 13 on ischemic stroke by activating AMPK/GSK-3β/Nrf2 signaling
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Author / Creator
Duan, Jialin , Cui, Jia , Yang, Zhifu , Guo, Chao , Cao, Jinyi , Xi, Miaomiao , Weng, Yan , Yin, Ying , Wang, Yanhua , Wei, Guo , Qiao, Boling and Wen, Aidong
Publisher
England: BioMed Central
Journal title
Language
English
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Publisher
England: BioMed Central
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Scope and Contents
Contents
Previous studies had showed that Apelin 13 could protect against apoptosis induced by ischemic/reperfusion (I/R). However, the mechanisms whereby Apelin 13 protected brain I/R remained to be elucidated. The present study was designed to determine whether Apelin 13 provided protection through AMPK/GSK-3β/Nrf2 pathway.
In vivo, the I/R model was i...
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Full title
Neuroprotective effect of Apelin 13 on ischemic stroke by activating AMPK/GSK-3β/Nrf2 signaling
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TN_cdi_doaj_primary_oai_doaj_org_article_62df7ff2c2df45f9b62a7d1817657ca3
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_62df7ff2c2df45f9b62a7d1817657ca3
Other Identifiers
ISSN
1742-2094
E-ISSN
1742-2094
DOI
10.1186/s12974-019-1406-7
