A novel rapamycin analog is highly selective for mTORC1 in vivo
A novel rapamycin analog is highly selective for mTORC1 in vivo
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Author / Creator
Schreiber, Katherine H. , Arriola Apelo, Sebastian I. , Yu, Deyang , Brinkman, Jacqueline A. , Velarde, Michael C. , Syed, Faizan A. , Liao, Chen-Yu , Baar, Emma L. , Carbajal, Kathryn A. , Sherman, Dawn S. , Ortiz, Denise , Brunauer, Regina , Yang, Shany E. , Tzannis, Stelios T. , Kennedy, Brian K. and Lamming, Dudley W.
Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
Rapamycin, an inhibitor of mechanistic Target Of Rapamycin Complex 1 (mTORC1), extends lifespan and shows strong potential for the treatment of age-related diseases. However, rapamycin exerts metabolic and immunological side effects mediated by off-target inhibition of a second mTOR-containing complex, mTOR complex 2. Here, we report the identifica...
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Full title
A novel rapamycin analog is highly selective for mTORC1 in vivo
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TN_cdi_doaj_primary_oai_doaj_org_article_62fe1b728b0148059e306c8857df6c69
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_62fe1b728b0148059e306c8857df6c69
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-019-11174-0
