Allosteric ligands control the activation of a class C GPCR heterodimer by acting at the transmembra...
Allosteric ligands control the activation of a class C GPCR heterodimer by acting at the transmembrane interface
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England: eLife Science Publications, Ltd
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Language
English
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England: eLife Science Publications, Ltd
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G protein-coupled receptors (GPCRs) are among the most promising drug targets. They often form homo- and heterodimers with allosteric cross-talk between receptor entities, which contributes to fine-tuning of transmembrane signaling. Specifically controlling the activity of GPCR dimers with ligands is a good approach to clarify their physiological r...
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Full title
Allosteric ligands control the activation of a class C GPCR heterodimer by acting at the transmembrane interface
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TN_cdi_doaj_primary_oai_doaj_org_article_637406475b8f4911855cad59cb27a13c
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_637406475b8f4911855cad59cb27a13c
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ISSN
2050-084X
E-ISSN
2050-084X
DOI
10.7554/eLife.70188
