Intrinsic activation of β-catenin signaling by CRISPR/Cas9-mediated exon skipping contributes to imm...
Intrinsic activation of β-catenin signaling by CRISPR/Cas9-mediated exon skipping contributes to immune evasion in hepatocellular carcinoma
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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Comprehensive analysis of clinical samples has recently identified molecular and immunological classification of hepatocellular carcinoma (HCC), and the
CTNNB1
(β-catenin)-mutated subtype exhibits distinctive characteristics of immunosuppressive tumor microenvironment. For clarifying the molecular mechanisms, we first established human and mo...
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Intrinsic activation of β-catenin signaling by CRISPR/Cas9-mediated exon skipping contributes to immune evasion in hepatocellular carcinoma
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TN_cdi_doaj_primary_oai_doaj_org_article_63c7a6b15ee74a9d819e44b8f20fa851
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_63c7a6b15ee74a9d819e44b8f20fa851
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ISSN
2045-2322
E-ISSN
2045-2322
DOI
10.1038/s41598-021-96167-0
