Substrate-bound outward-open structure of a Na+-coupled sialic acid symporter reveals a new Na+ site
Substrate-bound outward-open structure of a Na+-coupled sialic acid symporter reveals a new Na+ site
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Author / Creator
Wahlgren, Weixiao Y. , Dunevall, Elin , North, Rachel A. , Paz, Aviv , Scalise, Mariafrancesca , Bisignano, Paola , Bengtsson-Palme, Johan , Goyal, Parveen , Claesson, Elin , Caing-Carlsson, Rhawnie , Andersson, Rebecka , Beis, Konstantinos , Nilsson, Ulf J. , Farewell, Anne , Pochini, Lorena , Indiveri, Cesare , Grabe, Michael , Dobson, Renwick C. J. , Abramson, Jeff , Ramaswamy, S. , Friemann, Rosmarie , Naturvetenskapliga fakulteten , Department of Chemistry , Lund University , Kemiska institutionen , Centre for Analysis and Synthesis , Faculty of Science , Lunds universitet and Centrum för analys och syntes
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London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
Many pathogenic bacteria utilise sialic acids as an energy source or use them as an external coating to evade immune detection. As such, bacteria that colonise sialylated environments deploy specific transporters to mediate import of scavenged sialic acids. Here, we report a substrate-bound 1.95 Å resolution structure and subsequent characterisatio...
Alternative Titles
Full title
Substrate-bound outward-open structure of a Na+-coupled sialic acid symporter reveals a new Na+ site
Authors, Artists and Contributors
Author / Creator
Dunevall, Elin
North, Rachel A.
Paz, Aviv
Scalise, Mariafrancesca
Bisignano, Paola
Bengtsson-Palme, Johan
Goyal, Parveen
Claesson, Elin
Caing-Carlsson, Rhawnie
Andersson, Rebecka
Beis, Konstantinos
Nilsson, Ulf J.
Farewell, Anne
Pochini, Lorena
Indiveri, Cesare
Grabe, Michael
Dobson, Renwick C. J.
Abramson, Jeff
Ramaswamy, S.
Friemann, Rosmarie
Naturvetenskapliga fakulteten
Department of Chemistry
Lund University
Kemiska institutionen
Centre for Analysis and Synthesis
Faculty of Science
Lunds universitet
Centrum för analys och syntes
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TN_cdi_doaj_primary_oai_doaj_org_article_64411a096c2a4afbaca431c776617538
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_64411a096c2a4afbaca431c776617538
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-018-04045-7
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