Mutated clones driving leukemic transformation are already detectable at the single-cell level in CD...
Mutated clones driving leukemic transformation are already detectable at the single-cell level in CD34-positive cells in the chronic phase of primary myelofibrosis
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Author / Creator
Parenti, Sandra , Rontauroli, Sebastiano , Carretta, Chiara , Mallia, Selene , Genovese, Elena , Chiereghin, Chiara , Peano, Clelia , Tavernari, Lara , Bianchi, Elisa , Fantini, Sebastian , Sartini, Stefano , Romano, Oriana , Bicciato, Silvio , Tagliafico, Enrico , Della Porta, Matteo and Manfredini, Rossella
Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
Disease progression of myeloproliferative neoplasms is the result of increased genomic complexity. Since the ability to predict disease evolution is crucial for clinical decisions, we studied single-cell genomics and transcriptomics of CD34-positive cells from a primary myelofibrosis (PMF) patient who progressed to acute myeloid leukemia (AML) whil...
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Full title
Mutated clones driving leukemic transformation are already detectable at the single-cell level in CD34-positive cells in the chronic phase of primary myelofibrosis
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TN_cdi_doaj_primary_oai_doaj_org_article_644d99d3c3d744418f3c13018b7b3bc7
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_644d99d3c3d744418f3c13018b7b3bc7
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ISSN
2397-768X
E-ISSN
2397-768X
DOI
10.1038/s41698-021-00144-9
