Niche stiffness sustains cancer stemness via TAZ and NANOG phase separation
Niche stiffness sustains cancer stemness via TAZ and NANOG phase separation
About this item
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Author / Creator
Liu, Xinwei , Ye, Yingying , Zhu, Liling , Xiao, Xiaoyun , Zhou, Boxuan , Gu, Yuanting , Si, Hang , Liang, Huixin , Liu, Mingzhu , Li, Jiaqian , Jiang, Qiongchao , Li, Jiang , Yu, Shubin , Ma, Ruiying , Su, Shicheng , Liao, Jian-You and Zhao, Qiyi
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publication information
Publisher
London: Nature Publishing Group UK
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Scope and Contents
Contents
Emerging evidence shows that the biomechanical environment is required to support cancer stem cells (CSCs), which play a crucial role in drug resistance. However, how mechanotransduction signals regulate CSCs and its clinical significance has remained unclear. Using clinical-practice ultrasound elastography for patients’ lesions and atomic force mi...
Alternative Titles
Full title
Niche stiffness sustains cancer stemness via TAZ and NANOG phase separation
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Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_647b8e9e8f1e465d8e7465b5fd2e1721
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_647b8e9e8f1e465d8e7465b5fd2e1721
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-023-35856-y
