Clonal origin and development of high hyperdiploidy in childhood acute lymphoblastic leukaemia
Clonal origin and development of high hyperdiploidy in childhood acute lymphoblastic leukaemia
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Author / Creator
Woodward, Eleanor L. , Yang, Minjun , Moura-Castro, Larissa H. , van den Bos, Hilda , Gunnarsson, Rebeqa , Olsson-Arvidsson, Linda , Spierings, Diana C. J. , Castor, Anders , Duployez, Nicolas , Zaliova, Marketa , Zuna, Jan , Johansson, Bertil , Foijer, Floris , Paulsson, Kajsa , Övriga starka forskningsmiljöer , Faculty of Medicine , Medicinska fakulteten , Other Strong Research Environments , LUCC: Lund University Cancer Centre , Division of Clinical Genetics , Aneuploidy in cancer , Department of Laboratory Medicine , Avdelningen för klinisk genetik , Genetic and epigenetic studies of pediatric leukemia , Lunds universitet , Profilområden och andra starka forskningsmiljöer , Lund University , Institutionen för laboratoriemedicin , Profile areas and other strong research environments , Aneuploidi i cancer , LUCC: Lunds universitets cancercentrum and Genetiska och epigenetiska studier av barnleukemi
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publication information
Publisher
London: Nature Publishing Group UK
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Scope and Contents
Contents
High hyperdiploid acute lymphoblastic leukemia (HeH ALL), one of the most common childhood malignancies, is driven by nonrandom aneuploidy (abnormal chromosome numbers) mainly comprising chromosomal gains. In this study, we investigate how aneuploidy in HeH ALL arises. Single cell whole genome sequencing of 2847 cells from nine primary cases and on...
Alternative Titles
Full title
Clonal origin and development of high hyperdiploidy in childhood acute lymphoblastic leukaemia
Authors, Artists and Contributors
Author / Creator
Yang, Minjun
Moura-Castro, Larissa H.
van den Bos, Hilda
Gunnarsson, Rebeqa
Olsson-Arvidsson, Linda
Spierings, Diana C. J.
Castor, Anders
Duployez, Nicolas
Zaliova, Marketa
Zuna, Jan
Johansson, Bertil
Foijer, Floris
Paulsson, Kajsa
Övriga starka forskningsmiljöer
Faculty of Medicine
Medicinska fakulteten
Other Strong Research Environments
LUCC: Lund University Cancer Centre
Division of Clinical Genetics
Aneuploidy in cancer
Department of Laboratory Medicine
Avdelningen för klinisk genetik
Genetic and epigenetic studies of pediatric leukemia
Lunds universitet
Profilområden och andra starka forskningsmiljöer
Lund University
Institutionen för laboratoriemedicin
Profile areas and other strong research environments
Aneuploidi i cancer
LUCC: Lunds universitets cancercentrum
Genetiska och epigenetiska studier av barnleukemi
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Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_64d0d9d155f840b1a5e6a3ed8a02925f
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_64d0d9d155f840b1a5e6a3ed8a02925f
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-023-37356-5
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