Recurrent background mutations in WHI2 impair proteostasis and degradation of misfolded cytosolic pr...
Recurrent background mutations in WHI2 impair proteostasis and degradation of misfolded cytosolic proteins in Saccharomyces cerevisiae
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London: Nature Publishing Group UK
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Language
English
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London: Nature Publishing Group UK
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Proteostasis promotes viability at both the cellular and organism levels by maintaining a functional proteome. This requires an intricate protein quality control (PQC) network that mediates protein folding by molecular chaperones and removes terminally misfolded proteins via the ubiquitin proteasome system and autophagy. How changes within the PQC...
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Recurrent background mutations in WHI2 impair proteostasis and degradation of misfolded cytosolic proteins in Saccharomyces cerevisiae
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TN_cdi_doaj_primary_oai_doaj_org_article_64f77dfa53a840999b4b6e1865581fdb
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_64f77dfa53a840999b4b6e1865581fdb
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ISSN
2045-2322
E-ISSN
2045-2322
DOI
10.1038/s41598-017-04525-8
