Divergent engagements between adeno-associated viruses with their cellular receptor AAVR
Divergent engagements between adeno-associated viruses with their cellular receptor AAVR
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Author / Creator
Zhang, Ran , Xu, Guangxue , Cao, Lin , Sun, Zixian , He, Yong , Cui, Mengtian , Sun, Yuna , Li, Shentao , Li, Huapeng , Qin, Lan , Hu, Mingxu , Yuan, Zhengjia , Rao, Zipei , Ding, Wei , Rao, Zihe and Lou, Zhiyong
Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
Adeno-associated virus (AAV) receptor (AAVR) is an essential receptor for the entry of multiple AAV serotypes with divergent rules; however, the mechanism remains unclear. Here, we determine the structures of the AAV1-AAVR and AAV5-AAVR complexes, revealing the molecular details by which PKD1 recognizes AAV5 and PKD2 is solely engaged with AAV1. PK...
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Full title
Divergent engagements between adeno-associated viruses with their cellular receptor AAVR
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TN_cdi_doaj_primary_oai_doaj_org_article_65392197bcba492bad7e082068fe56c1
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_65392197bcba492bad7e082068fe56c1
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-019-11668-x
