NOS2-deficient mice with hypoxic necrotizing lung lesions predict outcomes of tuberculosis chemother...
NOS2-deficient mice with hypoxic necrotizing lung lesions predict outcomes of tuberculosis chemotherapy in humans
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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During active TB in humans a spectrum of pulmonary granulomas with central necrosis and hypoxia exists. BALB/c mice, predominantly used in TB drug development, do not reproduce this complex pathology thereby inaccurately predicting clinical outcome. We found that
Nos2
−/−
mice incapable of NO-production in immune cells as microbial defence...
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NOS2-deficient mice with hypoxic necrotizing lung lesions predict outcomes of tuberculosis chemotherapy in humans
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TN_cdi_doaj_primary_oai_doaj_org_article_653956e7764245f0bc27af8e6d730cfa
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_653956e7764245f0bc27af8e6d730cfa
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ISSN
2045-2322
E-ISSN
2045-2322
DOI
10.1038/s41598-017-09177-2
