Elevation of effective p53 expression sensitizes wild-type p53 breast cancer cells to CDK7 inhibitor...
Elevation of effective p53 expression sensitizes wild-type p53 breast cancer cells to CDK7 inhibitor THZ1
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Author / Creator
Wang, Yueyuan , Zhang, Zhihao , Mi, Xuguang , Li, Mingxi , Huang, Dan , Song, Tingting , Qi, Xiaoyan and Yang, Ming
Publisher
London: BioMed Central
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Language
English
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Publisher
London: BioMed Central
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Background The cyclin-dependent kinase 7 (CDK7) inhibitor THZ1 represses multiple cancer cells. However, its tumor-repressive efficiency in wild-type p53 breast cancer cells remains controversial. Methods We conducted various assays, including CCK8, colony formation, flow cytometry, western blotting, and lactate dehydrogenase release detection, to...
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Elevation of effective p53 expression sensitizes wild-type p53 breast cancer cells to CDK7 inhibitor THZ1
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TN_cdi_doaj_primary_oai_doaj_org_article_65da5079faff4a6e8dde3829f04c532d
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_65da5079faff4a6e8dde3829f04c532d
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ISSN
1478-811X
E-ISSN
1478-811X
DOI
10.1186/s12964-022-00837-z
