Structural dynamics of the E6AP/UBE3A-E6-p53 enzyme-substrate complex
Structural dynamics of the E6AP/UBE3A-E6-p53 enzyme-substrate complex
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London: Nature Publishing Group UK
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Language
English
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London: Nature Publishing Group UK
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Deregulation of the ubiquitin ligase E6AP is causally linked to the development of human disease, including cervical cancer. In complex with the E6 oncoprotein of human papillomaviruses, E6AP targets the tumor suppressor p53 for degradation, thereby contributing to carcinogenesis. Moreover, E6 acts as a potent activator of E6AP by a yet unknown mec...
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Structural dynamics of the E6AP/UBE3A-E6-p53 enzyme-substrate complex
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TN_cdi_doaj_primary_oai_doaj_org_article_665259f0303c4a7a8d8b890e1f4e21c3
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_665259f0303c4a7a8d8b890e1f4e21c3
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-018-06953-0
