sTREM2 cerebrospinal fluid levels are a potential biomarker for microglia activity in early‐stage Al...
sTREM2 cerebrospinal fluid levels are a potential biomarker for microglia activity in early‐stage Alzheimer's disease and associate with neuronal injury markers
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Author / Creator
Suárez‐Calvet, Marc , Kleinberger, Gernot , Araque Caballero, Miguel Ángel , Brendel, Matthias , Rominger, Axel , Alcolea, Daniel , Fortea, Juan , Lleó, Alberto , Blesa, Rafael , Gispert, Juan Domingo , Sánchez‐Valle, Raquel , Antonell, Anna , Rami, Lorena , Molinuevo, José L , Brosseron, Frederic , Traschütz, Andreas , Heneka, Michael T , Struyfs, Hanne , Engelborghs, Sebastiaan , Sleegers, Kristel , Van Broeckhoven, Christine , Zetterberg, Henrik , Nellgård, Bengt , Blennow, Kaj , Crispin, Alexander , Ewers, Michael and Haass, Christian
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publication information
Publisher
London: Nature Publishing Group UK
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More information
Scope and Contents
Contents
TREM2 is an innate immune receptor expressed on the surface of microglia. Loss‐of‐function mutations of
TREM2
are associated with increased risk of Alzheimer's disease (AD). TREM2 is a type‐1 protein with an ectodomain that is proteolytically cleaved and released into the extracellular space as a soluble variant (sTREM2), which can be measure...
Alternative Titles
Full title
sTREM2 cerebrospinal fluid levels are a potential biomarker for microglia activity in early‐stage Alzheimer's disease and associate with neuronal injury markers
Authors, Artists and Contributors
Author / Creator
Kleinberger, Gernot
Araque Caballero, Miguel Ángel
Brendel, Matthias
Rominger, Axel
Alcolea, Daniel
Fortea, Juan
Lleó, Alberto
Blesa, Rafael
Gispert, Juan Domingo
Sánchez‐Valle, Raquel
Antonell, Anna
Rami, Lorena
Molinuevo, José L
Brosseron, Frederic
Traschütz, Andreas
Heneka, Michael T
Struyfs, Hanne
Engelborghs, Sebastiaan
Sleegers, Kristel
Van Broeckhoven, Christine
Zetterberg, Henrik
Nellgård, Bengt
Blennow, Kaj
Crispin, Alexander
Ewers, Michael
Haass, Christian
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_66a474839c6c42ef9e3672464afae85b
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_66a474839c6c42ef9e3672464afae85b
Other Identifiers
ISSN
1757-4676,1757-4684
E-ISSN
1757-4684
DOI
10.15252/emmm.201506123
