Analysis and Molecular Determinants of HIV RNase H Cleavage Specificity at the PPT/U3 Junction
Analysis and Molecular Determinants of HIV RNase H Cleavage Specificity at the PPT/U3 Junction
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Publisher
Switzerland: MDPI AG
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Language
English
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Publisher
Switzerland: MDPI AG
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Contents
HIV reverse transcriptases (RTs) convert viral genomic RNA into double-stranded DNA. During reverse transcription, polypurine tracts (PPTs) resilient to RNase H cleavage are used as primers for plus-strand DNA synthesis. Nonnucleoside RT inhibitors (NNRTIs) can interfere with the initiation of plus-strand DNA synthesis by enhancing PPT removal, whi...
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Full title
Analysis and Molecular Determinants of HIV RNase H Cleavage Specificity at the PPT/U3 Junction
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TN_cdi_doaj_primary_oai_doaj_org_article_66a561ac49df452da142a3b7cea2d79b
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_66a561ac49df452da142a3b7cea2d79b
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ISSN
1999-4915
E-ISSN
1999-4915
DOI
10.3390/v13010131
