Pro-metastatic collagen lysyl hydroxylase dimer assemblies stabilized by Fe2+-binding
Pro-metastatic collagen lysyl hydroxylase dimer assemblies stabilized by Fe2+-binding
About this item
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Author / Creator
Guo, Hou-Fu , Tsai, Chi-Lin , Terajima, Masahiko , Tan, Xiaochao , Banerjee, Priyam , Miller, Mitchell D. , Liu, Xin , Yu, Jiang , Byemerwa, Jovita , Alvarado, Sarah , Kaoud, Tamer S. , Dalby, Kevin N. , Bota-Rabassedas, Neus , Chen, Yulong , Yamauchi, Mitsuo , Tainer, John A. , Phillips, George N. , Kurie, Jonathan M. and Argonne National Lab. (ANL), Argonne, IL (United States). Advanced Photon Source (APS)
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publication information
Publisher
London: Nature Publishing Group UK
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Scope and Contents
Contents
Collagen lysyl hydroxylases (LH1-3) are Fe
2+
- and 2-oxoglutarate (2-OG)-dependent oxygenases that maintain extracellular matrix homeostasis. High LH2 levels cause stable collagen cross-link accumulations that promote fibrosis and cancer progression. However, developing LH antagonists will require structural insights. Here, we report a 2 Å c...
Alternative Titles
Full title
Pro-metastatic collagen lysyl hydroxylase dimer assemblies stabilized by Fe2+-binding
Authors, Artists and Contributors
Author / Creator
Tsai, Chi-Lin
Terajima, Masahiko
Tan, Xiaochao
Banerjee, Priyam
Miller, Mitchell D.
Liu, Xin
Yu, Jiang
Byemerwa, Jovita
Alvarado, Sarah
Kaoud, Tamer S.
Dalby, Kevin N.
Bota-Rabassedas, Neus
Chen, Yulong
Yamauchi, Mitsuo
Tainer, John A.
Phillips, George N.
Kurie, Jonathan M.
Argonne National Lab. (ANL), Argonne, IL (United States). Advanced Photon Source (APS)
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Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_66b3577e6b604e7983c92825500bf879
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_66b3577e6b604e7983c92825500bf879
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-018-02859-z
