Structure-guided functional suppression of AML-associated DNMT3A hotspot mutations
Structure-guided functional suppression of AML-associated DNMT3A hotspot mutations
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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Contents
DNA methyltransferases DNMT3A- and DNMT3B-mediated DNA methylation critically regulate epigenomic and transcriptomic patterning during development. The hotspot DNMT3A mutations at the site of Arg822 (R882) promote polymerization, leading to aberrant DNA methylation that may contribute to the pathogenesis of acute myeloid leukemia (AML). However, th...
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Full title
Structure-guided functional suppression of AML-associated DNMT3A hotspot mutations
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TN_cdi_doaj_primary_oai_doaj_org_article_66c300182321413d800b92d88c96ad1f
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_66c300182321413d800b92d88c96ad1f
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-024-47398-y
