New benzoxazole derivatives as potential VEGFR-2 inhibitors and apoptosis inducers: design, synthesi...
New benzoxazole derivatives as potential VEGFR-2 inhibitors and apoptosis inducers: design, synthesis, anti-proliferative evaluation, flowcytometric analysis, and in silico studies
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Publisher
England: Taylor & Francis
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Language
English
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England: Taylor & Francis
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Contents
A new series of benzoxazole derivatives were designed and synthesised to have the main essential pharmacophoric features of VEGFR-2 inhibitors. Cytotoxic activities were evaluated for all derivatives against two human cancer cell lines, MCF-7 and HepG2. Also, the effect of the most cytotoxic derivatives on VEGFR-2 protein concentration was assessed...
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Full title
New benzoxazole derivatives as potential VEGFR-2 inhibitors and apoptosis inducers: design, synthesis, anti-proliferative evaluation, flowcytometric analysis, and in silico studies
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TN_cdi_doaj_primary_oai_doaj_org_article_67393c5d353040d2a6882e7cf732c5b3
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_67393c5d353040d2a6882e7cf732c5b3
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ISSN
1475-6366,1475-6374
E-ISSN
1475-6374
DOI
10.1080/14756366.2021.2015343
