The G protein-first activation mechanism of opioid receptors by Gi protein and agonists
The G protein-first activation mechanism of opioid receptors by Gi protein and agonists
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Publisher
England: Cambridge University Press
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Language
English
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Publisher
England: Cambridge University Press
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Contents
We report the G protein-first mechanism for activation of G protein-coupled receptors (GPCR) for the three closest subtypes of the opioid receptors (OR), μOR, κOR and δOR. We find that they couple to the inactive Gi protein-bound guanosine diphosphate (GDP)
prior
to agonist binding. The inactive Gi protein forms anchors to the intracellular l...
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Full title
The G protein-first activation mechanism of opioid receptors by Gi protein and agonists
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TN_cdi_doaj_primary_oai_doaj_org_article_676a22934c3a4ca381f55dea1e514230
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_676a22934c3a4ca381f55dea1e514230
Other Identifiers
ISSN
2633-2892
E-ISSN
2633-2892
DOI
10.1017/qrd.2021.7
