Unique ligand and kinase-independent roles of the insulin receptor in regulation of cell cycle, sene...
Unique ligand and kinase-independent roles of the insulin receptor in regulation of cell cycle, senescence and apoptosis
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Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
Insulin acts through the insulin receptor (IR) tyrosine kinase to exert its classical metabolic and mitogenic actions. Here, using receptors with either short or long deletion of the β-subunit or mutation of the kinase active site (K1030R), we have uncovered a second, previously unrecognized IR signaling pathway that is intracellular domain-depende...
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Full title
Unique ligand and kinase-independent roles of the insulin receptor in regulation of cell cycle, senescence and apoptosis
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TN_cdi_doaj_primary_oai_doaj_org_article_67ef010fde4a43c48ec2f88b1f796fbb
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_67ef010fde4a43c48ec2f88b1f796fbb
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-022-35693-5
