Halofuginone prevents inflammation and proliferation of high-altitude pulmonary hypertension by inhi...
Halofuginone prevents inflammation and proliferation of high-altitude pulmonary hypertension by inhibiting the TGF-β1/Smad signaling pathway
About this item
Full title
Author / Creator
Wang, Jiangtao , Guan, Lina , Yu, Jian , Ma, Bohua , Shen, Huihua , Xing, Guozhu , Xu, Yawei , Li, Qiufang , Liu, Juan , Xu, Qin , Shi, Wenhui , He, Jia , Huang, Yixuan , Yin, Dongfeng , Li, Wu and Wang, Rui
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
The inflammatory response of lung tissue and abnormal proliferation of pulmonary artery smooth muscle cells are involved in the pathogenesis of high-altitude pulmonary hypertension (HAPH). Halofuginone (HF), an active ingredient derivative of Chang Shan (
Dichroa febrifuga
Lour. [Hydrangeaceae]), has antiproliferative, antihypertrophic, antif...
Alternative Titles
Full title
Halofuginone prevents inflammation and proliferation of high-altitude pulmonary hypertension by inhibiting the TGF-β1/Smad signaling pathway
Authors, Artists and Contributors
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_67fa19fe74044dd9a8c21219b5878094
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_67fa19fe74044dd9a8c21219b5878094
Other Identifiers
ISSN
2045-2322
E-ISSN
2045-2322
DOI
10.1038/s41598-025-88258-z
