Antimicrobial Peptides Designed against the Ω-Loop of Class A β-Lactamases to Potentiate the Efficac...
Antimicrobial Peptides Designed against the Ω-Loop of Class A β-Lactamases to Potentiate the Efficacy of β-Lactam Antibiotics
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Publisher
Switzerland: MDPI AG
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Language
English
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Publisher
Switzerland: MDPI AG
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Contents
Class A serine β-lactamases (SBLs) have a conserved non-active site structural domain called the omega loop (Ω-loop), in which a glutamic acid residue is believed to be directly involved in the hydrolysis of β-lactam antibiotics by providing a water molecule during catalysis. We aimed to design and characterise potential pentapeptides to mask the f...
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Full title
Antimicrobial Peptides Designed against the Ω-Loop of Class A β-Lactamases to Potentiate the Efficacy of β-Lactam Antibiotics
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TN_cdi_doaj_primary_oai_doaj_org_article_681dd803041744f39a53d27fb6efc5d6
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_681dd803041744f39a53d27fb6efc5d6
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ISSN
2079-6382
E-ISSN
2079-6382
DOI
10.3390/antibiotics12030553
