Structural basis for botulinum neurotoxin E recognition of synaptic vesicle protein 2
Structural basis for botulinum neurotoxin E recognition of synaptic vesicle protein 2
About this item
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Author / Creator
Liu, Zheng , Lee, Pyung-Gang , Krez, Nadja , Lam, Kwok-ho , Liu, Hao , Przykopanski, Adina , Chen, Peng , Yao, Guorui , Zhang, Sicai , Tremblay, Jacqueline M. , Perry, Kay , Shoemaker, Charles B. , Rummel, Andreas , Dong, Min , Jin, Rongsheng and Argonne National Laboratory (ANL), Argonne, IL (United States). Advanced Photon Source (APS)
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publication information
Publisher
London: Nature Publishing Group UK
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Scope and Contents
Contents
Botulinum neurotoxin E (BoNT/E) is one of the major causes of human botulism and paradoxically also a promising therapeutic agent. Here we determined the co-crystal structures of the receptor-binding domain of BoNT/E (H
C
E) in complex with its neuronal receptor synaptic vesicle glycoprotein 2A (SV2A) and a nanobody that serves as a gangliosi...
Alternative Titles
Full title
Structural basis for botulinum neurotoxin E recognition of synaptic vesicle protein 2
Authors, Artists and Contributors
Author / Creator
Lee, Pyung-Gang
Krez, Nadja
Lam, Kwok-ho
Liu, Hao
Przykopanski, Adina
Chen, Peng
Yao, Guorui
Zhang, Sicai
Tremblay, Jacqueline M.
Perry, Kay
Shoemaker, Charles B.
Rummel, Andreas
Dong, Min
Jin, Rongsheng
Argonne National Laboratory (ANL), Argonne, IL (United States). Advanced Photon Source (APS)
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Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_689e4b646d7b448d89b2317de1ca4c69
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_689e4b646d7b448d89b2317de1ca4c69
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-023-37860-8
