Active thrombin produced by the intestinal epithelium controls mucosal biofilms
Active thrombin produced by the intestinal epithelium controls mucosal biofilms
About this item
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Author / Creator
Motta, Jean-Paul , Denadai-Souza, Alexandre , Sagnat, David , Guiraud, Laura , Edir, Anissa , Bonnart, Chrystelle , Sebbag, Mireille , Rousset, Perrine , Lapeyre, Ariane , Seguy, Carine , Mathurine-Thomas, Noa , Galipeau, Heather J. , Bonnet, Delphine , Alric, Laurent , Buret, Andre G. , Wallace, John L. , Dufour, Antoine , Verdu, Elena F. , Hollenberg, Morley D. , Oswald, Eric , Serino, Matteo , Deraison, Celine and Vergnolle, Nathalie
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publication information
Publisher
London: Nature Publishing Group UK
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More information
Scope and Contents
Contents
Proteolytic homeostasis is important at mucosal surfaces, but its actors and their precise role in physiology are poorly understood. Here we report that healthy human and mouse colon epithelia are a major source of active thrombin. We show that mucosal thrombin is directly regulated by the presence of commensal microbiota. Specific inhibition of lu...
Alternative Titles
Full title
Active thrombin produced by the intestinal epithelium controls mucosal biofilms
Authors, Artists and Contributors
Author / Creator
Denadai-Souza, Alexandre
Sagnat, David
Guiraud, Laura
Edir, Anissa
Bonnart, Chrystelle
Sebbag, Mireille
Rousset, Perrine
Lapeyre, Ariane
Seguy, Carine
Mathurine-Thomas, Noa
Galipeau, Heather J.
Bonnet, Delphine
Alric, Laurent
Buret, Andre G.
Wallace, John L.
Dufour, Antoine
Verdu, Elena F.
Hollenberg, Morley D.
Oswald, Eric
Serino, Matteo
Deraison, Celine
Vergnolle, Nathalie
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_68a8589ee36440b4a7b451d28d77ced9
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_68a8589ee36440b4a7b451d28d77ced9
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-019-11140-w
