Stabilization of Pin1 by USP34 promotes Ubc9 isomerization and protein sumoylation in glioma stem ce...
Stabilization of Pin1 by USP34 promotes Ubc9 isomerization and protein sumoylation in glioma stem cells
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Author / Creator
Zhu, Qiuhong , Liang, Panpan , Meng, Hao , Li, Fangzhen , Miao, Wei , Chu, Cuiying , Wang, Wei , Li, Dongxue , Chen, Cong , Shi, Yu , Yu, Xingjiang , Ping, Yifang , Niu, Chaoshi , Wu, Hai-bo , Zhang, Aili , Bian, Xiu-wu and Zhou, Wenchao
Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
The peptidyl-prolyl cis-trans isomerase Pin1 is a pivotal therapeutic target in cancers, but the regulation of Pin1 protein stability is largely unknown. High Pin1 expression is associated with SUMO1-modified protein hypersumoylation in glioma stem cells (GSCs), but the underlying mechanisms remain elusive. Here we demonstrate that Pin1 is deubiqui...
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Full title
Stabilization of Pin1 by USP34 promotes Ubc9 isomerization and protein sumoylation in glioma stem cells
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TN_cdi_doaj_primary_oai_doaj_org_article_68d6219593424984988e9b55888ae088
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_68d6219593424984988e9b55888ae088
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-023-44349-x
