Human DECR1 is an androgen-repressed survival factor that regulates PUFA oxidation to protect prosta...
Human DECR1 is an androgen-repressed survival factor that regulates PUFA oxidation to protect prostate tumor cells from ferroptosis
About this item
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Author / Creator
Nassar, Zeyad D , Mah, Chui Yan , Dehairs, Jonas , Burvenich, Ingrid Jg , Irani, Swati , Centenera, Margaret M , Helm, Madison , Shrestha, Raj K , Moldovan, Max , Don, Anthony S , Holst, Jeff , Scott, Andrew M , Horvath, Lisa G , Lynn, David J , Selth, Luke A , Hoy, Andrew J , Swinnen, Johannes V and Butler, Lisa M
Publisher
England: eLife Sciences Publications Ltd
Journal title
Language
English
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Publication information
Publisher
England: eLife Sciences Publications Ltd
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Scope and Contents
Contents
Fatty acid β-oxidation (FAO) is the main bioenergetic pathway in human prostate cancer (PCa) and a promising novel therapeutic vulnerability. Here we demonstrate therapeutic efficacy of targeting FAO in clinical prostate tumors cultured ex vivo, and identify
encoding the rate-limiting enzyme for oxidation of polyunsaturated fatty acids (PUFAs),...
Alternative Titles
Full title
Human DECR1 is an androgen-repressed survival factor that regulates PUFA oxidation to protect prostate tumor cells from ferroptosis
Authors, Artists and Contributors
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Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_691410c791b2452584ed62099c163640
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_691410c791b2452584ed62099c163640
Other Identifiers
ISSN
2050-084X
E-ISSN
2050-084X
DOI
10.7554/eLife.54166
