Negative modulation of mitochondrial calcium uniporter complex protects neurons against ferroptosis
Negative modulation of mitochondrial calcium uniporter complex protects neurons against ferroptosis
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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Ferroptosis is an iron- and reactive oxygen species (ROS)-dependent form of regulated cell death, that has been implicated in Alzheimer’s disease and Parkinson’s disease. Inhibition of cystine/glutamate antiporter could lead to mitochondrial fragmentation, mitochondrial calcium ([Ca
2+
]
m
) overload, increased mitochondrial ROS product...
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Negative modulation of mitochondrial calcium uniporter complex protects neurons against ferroptosis
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TN_cdi_doaj_primary_oai_doaj_org_article_691ff9c44b724f72bdd4f4130f56e6a5
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_691ff9c44b724f72bdd4f4130f56e6a5
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ISSN
2041-4889
E-ISSN
2041-4889
DOI
10.1038/s41419-023-06290-1
