Small Molecules Targeting Kidney ClC-K Chloride Channels: Applications in Rare Tubulopathies and Com...
Small Molecules Targeting Kidney ClC-K Chloride Channels: Applications in Rare Tubulopathies and Common Cardiovascular Diseases
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Publisher
Switzerland: MDPI AG
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Language
English
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Publisher
Switzerland: MDPI AG
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Given the key role played by ClC-K chloride channels in kidney and inner ear physiology and pathology, they can be considered important targets for drug discovery. Indeed, ClC-Ka and ClC-Kb inhibition would interfere with the urine countercurrent concentration mechanism in Henle’s loop, which is responsible for the reabsorption of water and electro...
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Full title
Small Molecules Targeting Kidney ClC-K Chloride Channels: Applications in Rare Tubulopathies and Common Cardiovascular Diseases
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TN_cdi_doaj_primary_oai_doaj_org_article_694c46b8ed9a4b64bb8362e47ff99510
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_694c46b8ed9a4b64bb8362e47ff99510
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ISSN
2218-273X
E-ISSN
2218-273X
DOI
10.3390/biom13040710
