TLR4 Overexpression Aggravates Bacterial Lipopolysaccharide-Induced Apoptosis via Excessive Autophag...
TLR4 Overexpression Aggravates Bacterial Lipopolysaccharide-Induced Apoptosis via Excessive Autophagy and NF-κB/MAPK Signaling in Transgenic Mammal Models
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Author / Creator
Wang, Sutian , Zhang, Kunli , Song, Xuting , Huang, Qiuyan , Lin, Sen , Deng, Shoulong , Qi, Meiyu , Yang, Yecheng , Lu, Qi , Zhao, Duowei , Meng, Fanming , Li, Jianhao , Lian, Zhengxing , Luo, Chenglong and Yao, Yuchang
Publisher
Switzerland: MDPI AG
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Language
English
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Publisher
Switzerland: MDPI AG
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Contents
Gram-negative bacterial infections pose a significant threat to public health. Toll-like receptor 4 (TLR4) recognizes bacterial lipopolysaccharide (LPS) and induces innate immune responses, autophagy, and cell death, which have major impacts on the body’s physiological homeostasis. However, the role of TLR4 in bacterial LPS-induced autophagy and ap...
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Full title
TLR4 Overexpression Aggravates Bacterial Lipopolysaccharide-Induced Apoptosis via Excessive Autophagy and NF-κB/MAPK Signaling in Transgenic Mammal Models
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TN_cdi_doaj_primary_oai_doaj_org_article_69529a78e8a140c5953752218409fe62
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_69529a78e8a140c5953752218409fe62
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ISSN
2073-4409
E-ISSN
2073-4409
DOI
10.3390/cells12131769
