CSF tau368/total-tau ratio reflects cognitive performance and neocortical tau better compared to p-t...
CSF tau368/total-tau ratio reflects cognitive performance and neocortical tau better compared to p-tau181 and p-tau217 in cognitively impaired individuals
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Author / Creator
Simrén, Joel , Brum, Wagner S. , Ashton, Nicholas J. , Benedet, Andrea L. , Karikari, Thomas K. , Kvartsberg, Hlin , Sjons, Emma , Lussier, Firoza Z. , Chamoun, Mira , Stevenson, Jenna , Hopewell, Robert , Pallen, Vanessa , Ye, Keqiang , Pascoal, Tharick A. , Zetterberg, Henrik , Rosa-Neto, Pedro and Blennow, Kaj
Publisher
England: BioMed Central Ltd
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Language
English
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Publisher
England: BioMed Central Ltd
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Contents
Cerebrospinal fluid (CSF) tau biomarkers are reliable diagnostic markers for Alzheimer's disease (AD). However, their strong association with amyloid pathology may limit their reliability as specific markers of tau neurofibrillary tangles. A recent study showed evidence that a ratio of CSF C-terminally truncated tau (tau368, a tangle-enriched tau s...
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Full title
CSF tau368/total-tau ratio reflects cognitive performance and neocortical tau better compared to p-tau181 and p-tau217 in cognitively impaired individuals
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TN_cdi_doaj_primary_oai_doaj_org_article_696a39d2f58b4396bc056504a06b2bf9
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_696a39d2f58b4396bc056504a06b2bf9
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ISSN
1758-9193
E-ISSN
1758-9193
DOI
10.1186/s13195-022-01142-0
