FIP200 controls the TBK1 activation threshold at SQSTM1/p62-positive condensates
FIP200 controls the TBK1 activation threshold at SQSTM1/p62-positive condensates
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Author / Creator
Schlütermann, David , Berleth, Niklas , Deitersen, Jana , Wallot-Hieke, Nora , Friesen, Olena , Wu, Wenxian , Stuhldreier, Fabian , Sun, Yadong , Berning, Lena , Friedrich, Annabelle , Mendiburo, María José , Peter, Christoph , Wiek, Constanze , Hanenberg, Helmut , Stefanski, Anja , Stühler, Kai and Stork, Björn
Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
The protein kinase TBK1 is a central regulator of innate immune responses and autophagy, and ablation of either function has been linked to neuroinflammatory or degenerative diseases. Autophagy is an intracellular process that recycles old or damaged proteins and organelles. In recent years, the TBK1-dependent regulation of autophagy pathways has b...
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Full title
FIP200 controls the TBK1 activation threshold at SQSTM1/p62-positive condensates
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TN_cdi_doaj_primary_oai_doaj_org_article_6972ad6fb1594ad394a0391385e1a71d
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_6972ad6fb1594ad394a0391385e1a71d
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ISSN
2045-2322
E-ISSN
2045-2322
DOI
10.1038/s41598-021-92408-4
