Integrating genome-wide CRISPR immune screen with multi-omic clinical data reveals distinct classes...
Integrating genome-wide CRISPR immune screen with multi-omic clinical data reveals distinct classes of tumor intrinsic immune regulators
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Author / Creator
Hou, Jiakai , Wang, Yunfei , Shi, Leilei , Chen, Yuan , Xu, Chunyu , Saeedi, Arash , Pan, Ke , Bohat, Ritu , Egan, Nicholas A. , McKenzie, Jodi A. , Mbofung, Rina M. , Williams, Leila J. , Yang, Zhenhuang , Sun, Ming , Liang, Xiaofang , Rodon Ahnert, Jordi , Varadarajan, Navin , Yee, Cassian , Chen, Yiwen , Hwu, Patrick and Peng, Weiyi
Publisher
England: BMJ Publishing Group LTD
Journal title
Language
English
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Publisher
England: BMJ Publishing Group LTD
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Scope and Contents
Contents
BackgroundDespite approval of immunotherapy for a wide range of cancers, the majority of patients fail to respond to immunotherapy or relapse following initial response. These failures may be attributed to immunosuppressive mechanisms co-opted by tumor cells. However, it is challenging to use conventional methods to systematically evaluate the pote...
Alternative Titles
Full title
Integrating genome-wide CRISPR immune screen with multi-omic clinical data reveals distinct classes of tumor intrinsic immune regulators
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Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_697d4fd89d6e46368db75489c262a019
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_697d4fd89d6e46368db75489c262a019
Other Identifiers
ISSN
2051-1426
E-ISSN
2051-1426
DOI
10.1136/jitc-2020-001819
