Proline metabolism supports metastasis formation and could be inhibited to selectively target metast...
Proline metabolism supports metastasis formation and could be inhibited to selectively target metastasizing cancer cells
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Publisher
London: Nature Publishing Group UK
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Language
English
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London: Nature Publishing Group UK
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Metastases are the leading cause of mortality in patients with cancer. Metastasis formation requires cancer cells to adapt their cellular phenotype. However, how metabolism supports this adaptation of cancer cells is poorly defined. We use 2D versus 3D cultivation to induce a shift in the cellular phenotype of breast cancer cells. We discover that...
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Proline metabolism supports metastasis formation and could be inhibited to selectively target metastasizing cancer cells
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TN_cdi_doaj_primary_oai_doaj_org_article_69af72ab34f4448d9adc1e35ac453ca9
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_69af72ab34f4448d9adc1e35ac453ca9
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/ncomms15267
