Poly(ADP-ribose) polymerase 1 accelerates vascular calcification by upregulating Runx2
Poly(ADP-ribose) polymerase 1 accelerates vascular calcification by upregulating Runx2
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Author / Creator
Wang, Cheng , Xu, Wenjing , An, Jie , Liang, Minglu , Li, Yiqing , Zhang, Fengxiao , Tong, Qiangsong and Huang, Kai
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publication information
Publisher
London: Nature Publishing Group UK
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Scope and Contents
Contents
Vascular calcification is highly prevalent in end-stage renal diseases and is predictive of cardiovascular events and mortality. Poly(ADP-ribose) polymerase 1 (PARP1) inhibition or deletion is vasoprotective in several disease models. Here we show that PARP activity is increased in radial artery samples from patients with chronic renal failure, in...
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Full title
Poly(ADP-ribose) polymerase 1 accelerates vascular calcification by upregulating Runx2
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Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_69ede5d3fbeb44789640a5683cea514a
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_69ede5d3fbeb44789640a5683cea514a
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-019-09174-1
