854 SGN-B7H4V, a novel, investigational vedotin antibody-drug conjugate directed to the T cell check...
854 SGN-B7H4V, a novel, investigational vedotin antibody-drug conjugate directed to the T cell checkpoint ligand B7-H4, shows promising activity in preclinical models
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Author / Creator
Gray, Elizabeth , Epp, Angela , Ulrich, Michelle , Sahetya, Disha , Hensley, Kelly , Hahn, Julie , Allred, Sean , Haass, Jane , Snead, Katie , Lucas, Sasha , Gosink, John , Boyce, Rogely , Trueblood, Esther , Treuting, Piper , Frantz, Chris , Smith, Alyson , Schrum, Jason , Nazarenko, Natalya and Gardai, Shyra
Publisher
London: BMJ Publishing Group Ltd
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Language
English
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London: BMJ Publishing Group Ltd
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Contents
BackgroundSGN-B7H4V is a novel, investigational vedotin antibody drug conjugate (ADC) directed to B7-H4, a member of the B7 family of immune checkpoint ligands. B7-H4 expression is elevated on a variety of solid tumors including breast, ovarian, and endometrial tumors.1 SGN-B7H4V is composed of a fully human IgG1 anti-B7-H4 monoclonal antibody (mAb...
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Full title
854 SGN-B7H4V, a novel, investigational vedotin antibody-drug conjugate directed to the T cell checkpoint ligand B7-H4, shows promising activity in preclinical models
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Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_69edefe076c94b3782fb3ef57afa2c8f
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_69edefe076c94b3782fb3ef57afa2c8f
Other Identifiers
E-ISSN
2051-1426
DOI
10.1136/jitc-2021-SITC2021.854
