Single-Strand Annealing Plays a Major Role in Double-Strand DNA Break Repair following CRISPR-Cas9 C...
Single-Strand Annealing Plays a Major Role in Double-Strand DNA Break Repair following CRISPR-Cas9 Cleavage in Leishmania
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Publisher
United States: American Society for Microbiology
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Language
English
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Publisher
United States: American Society for Microbiology
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Contents
Due to differences in double-strand DNA break (DSB) repair mechanisms, CRISPR-Cas9 gene editing efficiency can vary greatly in different organisms. In contrast to mammalian cells, the protozoan parasite
Leishmania
uses microhomology-mediated end joining (MMEJ) and, occasionally, homology-directed repair (HDR) to repair DSBs but lacks the nonh...
Alternative Titles
Full title
Single-Strand Annealing Plays a Major Role in Double-Strand DNA Break Repair following CRISPR-Cas9 Cleavage in Leishmania
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TN_cdi_doaj_primary_oai_doaj_org_article_6a04c6b29f2849d5825dd05b8dcbe129
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_6a04c6b29f2849d5825dd05b8dcbe129
Other Identifiers
ISSN
2379-5042
E-ISSN
2379-5042
DOI
10.1128/mSphere.00408-19
