Synthesis and bioactivities evaluation of oleanolic acid oxime ester derivatives as α-glucosidase an...
Synthesis and bioactivities evaluation of oleanolic acid oxime ester derivatives as α-glucosidase and α-amylase inhibitors
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Publisher
England: Taylor & Francis
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Language
English
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Publisher
England: Taylor & Francis
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Scope and Contents
Contents
Different oleanolic acid (OA) oxime ester derivatives (3a-3t) were designed and synthesised to develop inhibitors against α-glucosidase and α-amylase. All the synthesised OA derivatives were evaluated against α-glucosidase and α-amylase in vitro. Among them, compound 3a showed the highest α-glucosidase inhibition with an IC
50
of 0.35 µM, whi...
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Full title
Synthesis and bioactivities evaluation of oleanolic acid oxime ester derivatives as α-glucosidase and α-amylase inhibitors
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TN_cdi_doaj_primary_oai_doaj_org_article_6a3434ac43434813a7b334fc3c2f5e5e
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_6a3434ac43434813a7b334fc3c2f5e5e
Other Identifiers
ISSN
1475-6366
E-ISSN
1475-6374
DOI
10.1080/14756366.2021.2018682
