PPM1H phosphatase counteracts LRRK2 signaling by selectively dephosphorylating Rab proteins
PPM1H phosphatase counteracts LRRK2 signaling by selectively dephosphorylating Rab proteins
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England: eLife Sciences Publications Ltd
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English
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England: eLife Sciences Publications Ltd
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Mutations that activate LRRK2 protein kinase cause Parkinson’s disease. LRRK2 phosphorylates a subset of Rab GTPases within their Switch-II motif controlling interaction with effectors. An siRNA screen of all human protein phosphatases revealed that a poorly studied protein phosphatase, PPM1H, counteracts LRRK2 signaling by specifically dephosphory...
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PPM1H phosphatase counteracts LRRK2 signaling by selectively dephosphorylating Rab proteins
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TN_cdi_doaj_primary_oai_doaj_org_article_6a5369c02adb4cf08a138e9a247156ed
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_6a5369c02adb4cf08a138e9a247156ed
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ISSN
2050-084X
E-ISSN
2050-084X
DOI
10.7554/eLife.50416
