IgM anti-GM2 antibodies in patients with multifocal motor neuropathy target Schwann cells and are as...
IgM anti-GM2 antibodies in patients with multifocal motor neuropathy target Schwann cells and are associated with early onset
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Author / Creator
Budding, Kevin , Bos, Jeroen W. , Dijkxhoorn, Kim , de Zeeuw, Elisabeth , Bloemenkamp, Lauri M. , Zekveld, Eva M. , Groen, Ewout J.N. , Jacobs, Bart C. , Huizinga, Ruth , Goedee, H. Stephan , Cats, Elisabeth A. , Leusen, Jeanette H.W. , van den Berg, Leonard H. , Hack, C. Erik and van der Pol, W. Ludo
Publisher
England: BioMed Central Ltd
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Language
English
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Publisher
England: BioMed Central Ltd
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Scope and Contents
Contents
Multifocal motor neuropathy (MMN) is a rare, chronic immune-mediated polyneuropathy characterized by asymmetric distal limb weakness. An important feature of MMN is the presence of IgM antibodies against gangliosides, in particular GM1 and less often GM2. Antibodies against GM1 bind to motor neurons (MNs) and cause damage through complement activat...
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Full title
IgM anti-GM2 antibodies in patients with multifocal motor neuropathy target Schwann cells and are associated with early onset
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TN_cdi_doaj_primary_oai_doaj_org_article_6a575bd7333941c8bd8c09e509cbb6f7
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_6a575bd7333941c8bd8c09e509cbb6f7
Other Identifiers
ISSN
1742-2094
E-ISSN
1742-2094
DOI
10.1186/s12974-024-03090-y
