Genome-scale metabolic rewiring improves titers rates and yields of the non-native product indigoidi...
Genome-scale metabolic rewiring improves titers rates and yields of the non-native product indigoidine at scale
About this item
Full title
Author / Creator
Banerjee, Deepanwita , Eng, Thomas , Lau, Andrew K. , Sasaki, Yusuke , Wang, Brenda , Chen, Yan , Prahl, Jan-Philip , Singan, Vasanth R. , Herbert, Robin A. , Liu, Yuzhong , Tanjore, Deepti , Petzold, Christopher J. , Keasling, Jay D. , Mukhopadhyay, Aindrila and Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States)
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publication information
Publisher
London: Nature Publishing Group UK
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More information
Scope and Contents
Contents
High titer, rate, yield (TRY), and scalability are challenging metrics to achieve due to trade-offs between carbon use for growth and production. To achieve these metrics, we take the minimal cut set (MCS) approach that predicts metabolic reactions for elimination to couple metabolite production strongly with growth. We compute MCS solution-sets fo...
Alternative Titles
Full title
Genome-scale metabolic rewiring improves titers rates and yields of the non-native product indigoidine at scale
Authors, Artists and Contributors
Author / Creator
Eng, Thomas
Lau, Andrew K.
Sasaki, Yusuke
Wang, Brenda
Chen, Yan
Prahl, Jan-Philip
Singan, Vasanth R.
Herbert, Robin A.
Liu, Yuzhong
Tanjore, Deepti
Petzold, Christopher J.
Keasling, Jay D.
Mukhopadhyay, Aindrila
Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States)
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_6acc596583b948d89ae284839178e123
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_6acc596583b948d89ae284839178e123
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-020-19171-4
