HIF2α drives ccRCC metastasis through transcriptional activation of methylation-controlled J protein...
HIF2α drives ccRCC metastasis through transcriptional activation of methylation-controlled J protein and enhanced prolegumain secretion
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Shen, Tianyu , Su, Yu , Wang, Dekun , Li, Gang , Liu, Xuan , Sun, Chuangxin , Hu, Taoyu , Pang, Haoxiang , Mi, Xue , Zhang, Yuying , Yue, Shijing , Zhang, Zhujun and Tan, Xiaoyue
Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
The role of hypoxia-inducible factor 2α (HIF2α) in clear cell Renal Cell Carcinoma (ccRCC) is still not fully understood. In this study, we identified that urinary prolegumain levels positively correlated with the malignant characteristics of ccRCC. In cultured 786-O and OSRC-2 cells, HIF2α downregulation reduced prolegumain secretion. RNA sequenci...
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Full title
HIF2α drives ccRCC metastasis through transcriptional activation of methylation-controlled J protein and enhanced prolegumain secretion
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TN_cdi_doaj_primary_oai_doaj_org_article_6b30b763b2cc45e4a8f40f8479d57db1
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_6b30b763b2cc45e4a8f40f8479d57db1
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ISSN
2041-4889
E-ISSN
2041-4889
DOI
10.1038/s41419-025-07432-3
