The Molecular Pathogenesis of Small Cell Lung Cancer
The Molecular Pathogenesis of Small Cell Lung Cancer
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Tianjin: Chinese Anti-Cancer Association Chinese Antituberculosis Association
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Chinese
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Tianjin: Chinese Anti-Cancer Association Chinese Antituberculosis Association
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Note: Reprinted with the permission from the copyright holder© 2010 Landes Bioscience 图 1 作为细胞的“看门人”，p53作为细胞增殖的负性调节因子而发挥作用。P通过靶向作用于与cyclin D1/cdk4复合物结合的p21，p53可使细胞停滞于G期。p53诱导凋亡的其中一种机制便是通过增加Bax的合成；随后Bax阻滞具有抗凋亡作用的Bcl-2（见图2）。p16/Rb通路介导G/S期转化。Cyclin D1/cdk4复合物可磷酸化Rb。当Rb为磷酸化状态时，E2F被激活，可使细胞转化至S期。在S期，cyclinE和cdk2可调控Rb的磷酸化。 注：本图得到版权所有者© 2010 Landes Bioscie...
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The Molecular Pathogenesis of Small Cell Lung Cancer
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TN_cdi_doaj_primary_oai_doaj_org_article_6b821b7cc76e4d5ebd85f16b35e31def
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_6b821b7cc76e4d5ebd85f16b35e31def
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ISSN
1009-3419
E-ISSN
1999-6187
DOI
10.3779/cjlc.v13i11.1880
