BRCA1 and BRCA2 tumor suppressors protect against endogenous acetaldehyde toxicity
BRCA1 and BRCA2 tumor suppressors protect against endogenous acetaldehyde toxicity
About this item
Full title
Author / Creator
Tacconi, Eliana MC , Lai, Xianning , Folio, Cecilia , Porru, Manuela , Zonderland, Gijs , Badie, Sophie , Michl, Johanna , Sechi, Irene , Rogier, Mélanie , Matía García, Verónica , Batra, Ankita Sati , Rueda, Oscar M , Bouwman, Peter , Jonkers, Jos , Ryan, Anderson , Reina‐San‐Martin, Bernardo , Hui, Joannie , Tang, Nelson , Bruna, Alejandra , Biroccio, Annamaria and Tarsounas, Madalena
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publication information
Publisher
London: Nature Publishing Group UK
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More information
Scope and Contents
Contents
Maintenance of genome integrity requires the functional interplay between Fanconi anemia (FA) and homologous recombination (HR) repair pathways. Endogenous acetaldehyde, a product of cellular metabolism, is a potent source of DNA damage, particularly toxic to cells and mice lacking the FA protein FANCD2. Here, we investigate whether HR‐compromised...
Alternative Titles
Full title
BRCA1 and BRCA2 tumor suppressors protect against endogenous acetaldehyde toxicity
Authors, Artists and Contributors
Author / Creator
Lai, Xianning
Folio, Cecilia
Porru, Manuela
Zonderland, Gijs
Badie, Sophie
Michl, Johanna
Sechi, Irene
Rogier, Mélanie
Matía García, Verónica
Batra, Ankita Sati
Rueda, Oscar M
Bouwman, Peter
Jonkers, Jos
Ryan, Anderson
Reina‐San‐Martin, Bernardo
Hui, Joannie
Tang, Nelson
Bruna, Alejandra
Biroccio, Annamaria
Tarsounas, Madalena
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_6bb88c58f3cf4cfc896831d828ae3700
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_6bb88c58f3cf4cfc896831d828ae3700
Other Identifiers
ISSN
1757-4676,1757-4684
E-ISSN
1757-4684
DOI
10.15252/emmm.201607446
