Nuclear Smad6 promotes gliomagenesis by negatively regulating PIAS3-mediated STAT3 inhibition
Nuclear Smad6 promotes gliomagenesis by negatively regulating PIAS3-mediated STAT3 inhibition
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Author / Creator
Jiao, Jiantong , Zhang, Rui , Li, Zheng , Yin, Ying , Fang, Xiangming , Ding, Xiaopeng , Cai, Ying , Yang, Shudong , Mu, Huijun , Zong, Da , Chen, Yuexin , Zhang, Yansong , Zou, Jian , Shao, Junfei and Huang, Zhaohui
Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
To date, the molecular mechanism underlying constitutive signal transducer and activator of transcription 3 (STAT3) activation in gliomas is largely unclear. In this study, we report that Smad6 is overexpressed in nuclei of glioma cells, which correlates with poor patient survival and regulates STAT3 activity via negatively regulating the Protein I...
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Full title
Nuclear Smad6 promotes gliomagenesis by negatively regulating PIAS3-mediated STAT3 inhibition
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Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_6bf4d49429d84fb48d663f6dd8ad532c
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_6bf4d49429d84fb48d663f6dd8ad532c
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-018-04936-9
