Late-life targeting of the IGF-1 receptor improves healthspan and lifespan in female mice
Late-life targeting of the IGF-1 receptor improves healthspan and lifespan in female mice
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Author / Creator
Mao, Kai , Quipildor, Gabriela Farias , Tabrizian, Tahmineh , Novaj, Ardijana , Guan, Fangxia , Walters, Ryan O. , Delahaye, Fabien , Hubbard, Gene B. , Ikeno, Yuji , Ejima, Keisuke , Li, Peng , Allison, David B. , Salimi-Moosavi, Hossein , Beltran, Pedro J. , Cohen, Pinchas , Barzilai, Nir and Huffman, Derek M.
Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
Diminished growth factor signaling improves longevity in laboratory models, while a reduction in the somatotropic axis is favorably linked to human aging and longevity. Given the conserved role of this pathway on lifespan, therapeutic strategies, such as insulin-like growth factor-1 receptor (IGF-1R) monoclonal antibodies (mAb), represent a promisi...
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Full title
Late-life targeting of the IGF-1 receptor improves healthspan and lifespan in female mice
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TN_cdi_doaj_primary_oai_doaj_org_article_6c2da7569db9463080f4475bda1b2e80
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_6c2da7569db9463080f4475bda1b2e80
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-018-04805-5
