Primary tumors release ITGBL1-rich extracellular vesicles to promote distal metastatic tumor growth...
Primary tumors release ITGBL1-rich extracellular vesicles to promote distal metastatic tumor growth through fibroblast-niche formation
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Author / Creator
Ji, Qing , Zhou, Lihong , Sui, Hua , Yang, Liu , Wu, Xinnan , Song, Qing , Jia, Ru , Li, Ruixiao , Sun, Jian , Wang, Ziyuan , Liu, Ningning , Feng, Yuanyuan , Sun, Xiaoting , Cai, Gang , Feng, Yu , Cai, Jianfeng , Cao, Yihai , Cai, Guoxiang , Wang, Yan and Li, Qi
Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
Tumor metastasis is a hallmark of cancer. Metastatic cancer cells often reside in distal tissues and organs in their dormant state. Mechanisms underlying the pre-metastatic niche formation are poorly understood. Here we show that in a colorectal cancer (CRC) model, primary tumors release integrin beta-like 1 (ITGBL1)-rich extracellular vesicles (EV...
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Full title
Primary tumors release ITGBL1-rich extracellular vesicles to promote distal metastatic tumor growth through fibroblast-niche formation
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Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_6c5236b721274f3a8bd1e08b42a1fdf5
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_6c5236b721274f3a8bd1e08b42a1fdf5
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-020-14869-x
