Oncolytic adeno-immunotherapy modulates the immune system enabling CAR T-cells to cure pancreatic tu...
Oncolytic adeno-immunotherapy modulates the immune system enabling CAR T-cells to cure pancreatic tumors
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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High expression levels of human epidermal growth factor receptor 2 (HER2) have been associated with poor prognosis in patients with pancreatic adenocarcinoma (PDAC). However, HER2-targeting immunotherapies have been unsuccessful to date. Here we increase the breadth, potency, and duration of anti-PDAC HER2-specific CAR T-cell (HER2.CART) activity w...
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Oncolytic adeno-immunotherapy modulates the immune system enabling CAR T-cells to cure pancreatic tumors
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TN_cdi_doaj_primary_oai_doaj_org_article_6c619b9e136441a696783c518011c56f
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_6c619b9e136441a696783c518011c56f
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ISSN
2399-3642
E-ISSN
2399-3642
DOI
10.1038/s42003-021-01914-8
