Polygenic prediction via Bayesian regression and continuous shrinkage priors
Polygenic prediction via Bayesian regression and continuous shrinkage priors
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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Polygenic risk scores (PRS) have shown promise in predicting human complex traits and diseases. Here, we present PRS-CS, a polygenic prediction method that infers posterior effect sizes of single nucleotide polymorphisms (SNPs) using genome-wide association summary statistics and an external linkage disequilibrium (LD) reference panel. PRS-CS utili...
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Polygenic prediction via Bayesian regression and continuous shrinkage priors
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TN_cdi_doaj_primary_oai_doaj_org_article_6c6882b541884b08be03470e789b8afe
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_6c6882b541884b08be03470e789b8afe
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-019-09718-5
