Disturbances in the FGFR1-5-HT1A Heteroreceptor Complexes in the Raphe-Hippocampal 5-HT System Devel...
Disturbances in the FGFR1-5-HT1A Heteroreceptor Complexes in the Raphe-Hippocampal 5-HT System Develop in a Genetic Rat Model of Depression
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Borroto-Escuela, Dasiel O , DuPont, Caitlin M , Li, Xiang , Savelli, David , Lattanzi, Davide , Srivastava, Ipsit , Narváez, Manuel , Di Palma, Michael , Barbieri, Elisa , Andrade-Talavera, Yuniesky , Cuppini, Riccardo , Odagaki, Yuji , Palkovits, Miklos , Ambrogini, Patrizia , Lindskog, Maria and Fuxe, Kjell
Publisher
Switzerland: Frontiers Research Foundation
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English
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Switzerland: Frontiers Research Foundation
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Contents
The FGFR1-5-HT1A heteroreceptor complexes are involved in neuroplasticity in the rat hippocampus and in the mesencephalic raphe 5-HT nerve cells. There exists a 5-HT1A protomer enhancement of FGFR1 protomer signaling. Acute and 10 day treatment with intracerebroventricular (i.c.v.) FGF-2 and the 5-HT1A agonist 8-OH-DPAT produced enhanced antidepres...
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Full title
Disturbances in the FGFR1-5-HT1A Heteroreceptor Complexes in the Raphe-Hippocampal 5-HT System Develop in a Genetic Rat Model of Depression
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TN_cdi_doaj_primary_oai_doaj_org_article_6c7d2dceab9b42ec8eef5631d9ea14fc
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_6c7d2dceab9b42ec8eef5631d9ea14fc
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ISSN
1662-5102
E-ISSN
1662-5102
DOI
10.3389/fncel.2017.00309
