T cell receptor recognition of hybrid insulin peptides bound to HLA-DQ8
T cell receptor recognition of hybrid insulin peptides bound to HLA-DQ8
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Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Scope and Contents
Contents
HLA-DQ8, a genetic risk factor in type I diabetes (T1D), presents hybrid insulin peptides (HIPs) to autoreactive CD4+ T cells. The abundance of spliced peptides binding to HLA-DQ8 and how they are subsequently recognised by the autoreactive T cell repertoire is unknown. Here we report, the HIP (
GQV
E
LGGG
NAV
E
VLK), derived from...
Alternative Titles
Full title
T cell receptor recognition of hybrid insulin peptides bound to HLA-DQ8
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TN_cdi_doaj_primary_oai_doaj_org_article_6cfc61766a5b4c9d973ece4ad2e9ab57
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_6cfc61766a5b4c9d973ece4ad2e9ab57
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-021-25404-x
